Subjects exposed to strings of letters generated by a finite state grammar can later classify grammatical and nongrammatical test strings, even though they cannot adequately say what the rules of the grammar are (e.g., Reber, 1989). The MINERVA 2 (Hintzman, 1986) and Medin and Schaffer (1978) memory‐array models and a number of connectionist outoassociator models are tested against experimental data by deriving mainly parameter‐free predictions from the models of the rank order of classification difficulty of test strings. The importance of (...) different assumptions regarding the coding of features (How should the absence of a feature be coded? Should single letters or digrams be coded?), the learning rule used (Hebb rule vs. delta rule), and the connectivity (Should features be predicted only by previous features in the string, or by all features simultaneously?) is investigated by determining the performance of the models with and without each assumption. Only one class of connectionist model (the simultaneous delta rule) passes all the tests. It is shown that this class of model can be regarded by abstracting a set of representative but incomplete rules of the grammar. (shrink)

This anthology provides a collection of new essays on ethical and philosophical issues that concern the development, dispensing, and use of pharmaceuticals. It brings together critical ethical issues in pharmaceutics that have not been included in any collection (e.g., the ethics of patients as researchers). In addition, it includes philosophical issues that are not within the traditional domain of applied ethics. For example, a game-theoretic approach to combating the emergence of antibiotic-resistent pathogens by spreading altruism. A tripartite distinction provides an (...) organized series of discussions that shows the interrelatedness of philosophical issues from the creation of pharmaceuticals, the creation of demand for them, through their delivery to their ultimate consumption. (shrink)

Grapheme-colour synaesthesia is a perceptual experience where graphemes, letters or words evoke a specific colour, which are experienced either as spatially coincident with the grapheme inducer (projector sub-type) or elsewhere, perhaps without a definite spatial location (associator sub-type). Here, we address the question of whether synaesthesia can be rapidly produced using a hypnotic colour suggestion to examine the possibility of ‘hypnotic synaesthesia’, i.e. subjectively experienced colour hallucinations similar to those experienced by projector synaesthetes. We assess the efficacy of this intervention (...) using an “embedded figures” test, in which participants are required to detect a shape (e.g., a square) composed of local graphemic elements. For grapheme-colour synaesthetes, better performance on the task has been linked to a higher proportion of graphemes perceived as coloured. We found no performance benefits on this test when using a hypnotic suggestion, as compared to a no-suggestion control condition. The same result was found when participants were separated according to the degree to which they were susceptible to the suggestion (number of coloured trials perceived). However, we found a relationship between accuracy and subjective reports of colour in those participants who reported a large proportion of coloured trials: trials in which the embedded figure was accurately recognised (relative to trials in which it was not) were associated with reports of more intense colours occupying a greater spatial extent. Collectively, this implies that hypnotic colour was only perceived after shape detection rather than aiding in shape detection via colour-based perceptual grouping. The results suggest that hypnotically induced colours are not directly comparable to synaesthetic ones. (shrink)

Modern scholars have been concerned with the hostility shown to Alexander by the Hellenistic schools of philosophy. Two literary portraits have been distinguished, the Peripatetic and the Stoic, the former deriving from Theophrastus' book on Callisthenes, or starting with this work the Peripatetics worked out a theory of and applied it to Alexander, in order to belittle his achievements. It was a case of giving sophisticated expression to the kind of crude resentment expressed by Demades.

The locus classicus for Plutarch's own views on his methods is in the Alexander He has begun by asking for the indulgence of his readers if they do not find all the exploits of Alexander and Caesar recounted by the biographer or if they discover him not reporting some famous incident in detail (); and he goes on to compare his own search for evidence which will indicate the kind of soul, with the activity of the painter, who, in order (...) to create a likeness, concentrates on the eyes and pays little attention to the other parts. Commentators and critics have been right to take this as a key text for the purpose of understanding Plutarch's attitude towards his biographical work; nevertheless there are other passages in the Lives where we can at least glimpse his attitude to his subject, and we can only see the Alexander-remarks in correct perspective if we take these other passages into account. I propose therefore, starting with the Alexander, to see how far these critical remarks apply to Plutarch's theory and practice elsewhere in the Lives. (shrink)

According to the Ars Amatoria the notorious rape took place on the occasion of a primitive dramatic entertainment staged in a theatre, in which the seats and furnishings were also primitive. There is no time for a description of the arts of the performers—a tibicen and a ludius—before the Romans, impatient for action, receive their signal from Romulus. Nor is there any mention of a god in whose honour the entertainment had been provided.

What role does the wild duck play in Ibsen's famous drama? I argue that, besides mirroring the fate of the human cast members, the duck is acting as animal subject in a quasi-experiment, conducted in a private setting. Analysed from this perspective, the play allows us to discern the epistemological and ethical dimensions of the new scientific animal practice (systematic observation of animal behaviour under artificial conditions) emerging precesely at that time. Ibsen's play stages the clash between a scientific and (...) a romantic understanding of animals that still constitutes the backdrop of most contemporary debates over animals in research. Whereas the scientific understanding reduces the animal's behaviour, as well as its environment, to discrete and modifiable elements, the romantic view regards animals as being at one with (or violently disconnected from) their natural surroundings. (shrink)

In this paper, I will reread the history of molecular genetics from a psychoanalytical angle, analysing it as a case history. Building on the developmental theories of Freud and his followers, I will distinguish four stages, namely: (1) oedipal childhood, notably the epoch of model building (1943–1953); (2) the latency period, with a focus on the development of basic skills (1953–1989); (3) adolescence, exemplified by the Human Genome Project, with its fierce conflicts, great expectations and grandiose claims (1989–2003) and (4) (...) adulthood (2003–present) during which revolutionary research areas such as molecular biology and genomics have achieved a certain level of normalcy—have evolved into a normal science. I will indicate how a psychoanalytical assessment conducted in this manner may help us to interpret and address some of the key normative issues that have been raised with regard to molecular genetics over the years, such as ‘relevance’, ‘responsible innovation’ and ‘promise management’. (shrink)

Dienes & Perner argue that the explicit representation of an individual to which a property is attributed requires explicit representation of the attributed property. The reasons for this conclusion are similar to the reasons why another of their conclusions may be considered suspect: A property may be explicit without an explicit representation of an individual or the predication of the property to an individual. We question the latter conclusion and draw connections to neurophysiological and cognitive evidence.

Precision Medicine is driven by the idea that the rapidly increasing range of relatively cheap and efficient self-tracking devices make it feasible to collect multiple kinds of phenotypic data. Advocates of N = 1 research emphasize the countless opportunities personal data provide for optimizing individual health. At the same time, using biomarker data for lifestyle interventions has shown to entail complex challenges. In this paper, we argue that researchers in the field of precision medicine need to address the performative dimension (...) of collecting data. We propose the fun-house mirror as a metaphor for the use of personal health data; each health data source yields a particular type of image that can be regarded as a ‘data mirror’ that is by definition specific and skewed. This requires competence on the part of individuals to adequately interpret the images thus provided. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hazel E. Barnes FLAUBERT AND SARTRE ON MADNESS IN KING LEAR T'oward the end of the second volume of The Family Idiot (L'Idiot de la famille), in a section called "Exercises and Reading," Sartre discusses Flaubert's reading of Shakespeare.1 In the context Sartre describes how Flaubert spent his time during one of the rare periods when he was not even attempting to write anything; more than two years elapsed (...) between the completion of the first Sentimental Education in January 1845 and die beginning of his collaboration widi Maxime Du Camp on La Bretagne. Along with doing desultory background reading for "an oriental tale," and analyzing the plays ofVoltaire, Flaubert claimed to be studying the Greek and Roman authors and a selected few of the later "great immortals." Sartre shows that Flaubert's way of reading them was entirely different from the critical analysis which he directed on the work of his contemporaries. Essentially it was a series of"rereadings," and its purpose was not to gain knowledge or even a fuller understanding of the text. In a letter to Mlle de Chantepie, Flaubert counsels her to take one of the great writers and "study him in depth," reading from beginning to end and then starting over again: "But do not read, as children read, to amuse yourself, nor as the ambitious read, to instruct yourself. No, read so as to live. Create in your soul an intellectual atmosphere which will be compounded from the emanation of all the great minds."2 How can Flaubert both counsel his correspondent to study in depdi and not to seek instruction? The kind ofstudy he has in mind, Sartre claims, is comparable to the way in which an amateur pianist might "study" Chopin, where die aim is not to understand analytically but to perfect a particular interpretation and to evoke a certain aesdietic reaction. Flaubert resists instruction because new knowledge risks forcing change. What he wants is 211 2 1 2 Philosophy and Literature to rediscover the same eternal truths and emotions.3 It is also to find inspiration for his own dreams, an oneiric reading. In this connection Sartre makes two important points. First, in striving to cultivate for the soul "an intellectual atmosphere... compounded from the emanation of all the great minds," the artist is adding so many strings to his lyre — the laugh of Rabelais, the cosmic passions of Shakespeare, the skepticism of Montaigne. This is whyJules at the end of die first Sentimental Education plans to study die great writers, beginning with Homer — not to learn dieir technique but to enlarge the artist's sensibility. Sartre's second point is made apropos of Flaubert's rereading of Shakespeare. Flaubert fluctuates between two responses. Sometimes he is depressed at the thought of his own lack of genius in comparison with Shakespeare. "That good man will drive me mad.... All odiers seem to me children beside him."* At odier times he experiences what Sartre calls a "glorifying identification." It is as though in imagination he becomes Shakespeare. In part this is because, as he writes in this same letter, we artists "breathe in our existence by means of die sentence." Sartre notes that for Flaubert the existence in question is a literary reality, not that of die everyday world; we may breathe it in either dirough writing or through reading. At this particular moment in his life, Sartre argues, Flaubert's program of study was in bad faith. He allowed die imaginary identification to suffice. Sartre goes so far as to say, "He reads in order not to write; in diis masturbatory substitute for the act, he makes himself an aumor all at once, under anodier name, in order not to work at becoming the writer of genius he wants to be." This comment makes sense if we recall Flaubert's situation in 1845-47. After the nervous crisis at Pont-L'Evêque he knew that either he would be a writer or he would remain a feeble invalid, an object of pity, the "family idiot." "There he is, dien, paralyzed by two opposing forces: hope and die fear of being disappointed " (p. 2021). No wonder he... (shrink)

Metaphors for describing the introduction, impacts, and management of non-native species are numerous and often quite outspoken. Policy-makers have adopted increasingly disputed metaphorical terms from scientific discourse. We performed a critical analysis of the use of strong metaphors in reporting scientific findings to policy-makers. Our analysis shows that perceptions of harm, invasiveness or nativeness are dynamic and inevitably display multiple narratives in science, policy or management. Improving our awareness of multiple expert and stakeholder narratives that exist in the context of (...) non-native species management, as well as metaphorical alternatives, is critical. (shrink)

This book provides an introduction to Plato’s work that gives a clear statement of what Plato has to say about the problems of thought and life. In particular, it tells the reader just what Plato says, and makes no attempt to force a system on the Platonic text or to trim Plato’s works to suit contemporary philosophical tastes. The author also gives an account that has historical fidelity - we cannot really understand the Republic or the Gorgias if we forget (...) that the Athens of the conversations is meant to be the Athens of Nicias or Cleon, not the very different Athens of Plato’s own manhood. To understand Plato’s thought we must see it in the right historical perspective. (shrink)

This paper offers a new approach to the philosophical foundations of information systems through feminist philosophy and, in particular, feminist epistemology. This can be used to expose the universalizing tendency of many information systems and to show the importance of using real-life complex examples rather than the simplified examples often favored by philosophers. Within traditional epistemology and its relation to IS, subjectivity, the propositional/skills distinction and epistemic hierarchies are subject to arguments from feminist epistemology. With respect to the emerging critical (...) school of IS, feminist epistemology, and within that, feminist standpoint theory, are used to examine the complexities of the positivist/anti-positivist position and the related concept of emancipation. In addition, it is argued that the liberal version of emancipation encapsulated in such systems may have an effect opposite to that of emancipation These issues are illustrated in an existing expert systems project. (shrink)

The poet’s words: “A man’s reach should exceed his grasp” are not merely a command of what ought to be , they are a description of what is. Man has always been stretching himself beyond his own measure. He has a sense of the Infinite: Eternity has been set in his heart: he has not been content to look only on the things seen, his gaze has ever been towards the Unseen. Whatever stage of development he may have reached, he (...) seeks for, and strives after, what is above and beyond himself and his world. In science he tries to get behind the phenomenal reality as his senses apprehend it, to the noumenal , mind. In philosophy he endeavours to bring the multiplicity of his experience, outer and inner, into a unity that will evidence itself to his reason as coherent, and not contradictory. In morality he is not content with the customs and standards of the society of which he is a member; but conscious of their inadequacy, he conceives and aspires to realize an ideal adequate to his nature; his ought to be is always challenging his is . The impulse or motive of progress in all spheres of human interest and activity is “the best is yet to be.”. (shrink)